A Systematic Framework for StarLinker Dual-Payload ADC Optimization: Moving Beyond ‘Copy-and-Paste’ Design
- Mechanism-Driven Optimization: Moving past rigid "me-too" platforms to systematically tune payload selection, potency, ratios, and DAR to maximize initial efficacy while mitigating overlapping toxicities
- An Expanding Modular Library: Translating proven trends across multiple ongoing target programs into a scalable, target-specific linker–payload matching platform
- Robust In Vivo Validation: Utilizing a well-characterized Ab to rigorously validate the engineering blueprint and overcome TOP1i class resistance
- Immune-Stimulating Integration: Expanding the platform to integrate immunestimulating conjugates, unlocking a dual-attack mechanism for difficult-to-treat cancers