Developing a Novel Cytotoxic & Immunogenic Payload Class for the Next Generation of ADCs

  • Examine the rationale for payloads that induce immunogenic cell death (ICD) rather than relying on conventional cytotoxic mechanisms alone
  • Compare the activity of Ryvu's lead payload candidates against established ADC payloads across multiple tumor targets and models
  • Understand how novel payload mechanisms can expand therapeutic opportunities, improve differentiation, and address emerging resistance in the ADC landscape