Roundtable Discussion: Enhancing Payload Selection & Clinical Translation Through Human-Relevant Models to Increase Predictive Confidence
- Collaborate with peers to identify why promising ADC payloads frequently fail in clinical development, exploring the translational challenges associated with efficacy, toxicity, exposure, and resistance
- Discuss how organoids, tissue-on-chip platforms, microfluidic systems, and other human-relevant models can improve payload selection and uncover safety liabilities earlier in development
- Exchange lessons learned and practical solutions for building more predictive preclinical strategies, before sharing key recommendations with the wider audience to help improve ADC development success rates