Patrick Strout
Senior Scientist AstraZeneca
Seminars
Thursday 5th November 2026
From Design to Discontinuation: A DNA-Targeting ADC Payload Case Study in Translational Tolerability Challenges
1:30 pm
- End-to-end case study of a DNA-targeting ADC program, from payload selection and antibody pairing through to in vitro and in vivo evaluation
- Exploration of key chemistry and biology challenges, including conjugation strategy, assay predictivity, and species-dependent translational gaps
- Deep dive into tolerability outcomes in higher-order species and the critical learnings that shaped program termination and future redesign strategies
