Roundtable Discussion: Navigating the Evolution of ADC Payloads – From Topo1 Success to Future Innovation
Time: 11:45 am
day: Conference Day One
Details:
Take a break from presentations to connect with fellow payload experts and discuss why Topo1 inhibitors dominated the clinic so fast, what other modes of action and payload classes need to do to match that clinical success, and where there is whitespace for novel payloads to gain ground in a competitive ADC landscape.
Key Discussion Topics:
- Assess the current state of the payload field: How has the surge in payload diversity impacted your work, and what does it mean for potential applications and indications?
- Benchmarking requirements: What technical and clinical milestones must novel payloads achieve to achieve success?
- Post-Topo era: What emerging payload classes show promise to match the rate of growth of Topo I Inhibitors?
- Learning from the past: What historical challenges have limited the broad clinical success of certain payload classes and how can we ensure the next generation of payloads overcome those limitations?
