Structural Optimization of Amanitin-Based RNA Polymerase II Inhibitor Payloads for TROP2 Targeting ADCs
Time: 11:15 am
day: Conference Day One
Details:
- Understanding the evolution from first-generation (HTP101) to second-generation amanitin payloads demonstrating improved targeting capabilities through both cleavable and non-cleavable linker strategies
- Outlining structural optimization of amanitin payload to enhance overall performance
- Discussing the efficacy of TROP2-expressing tumors in both pancreatic and triplenegative breast cancer models
