Torsten Hechler

Company: Heidelberg Pharma

Job title: Senior Vice President ADC Research

Seminars:

Structural Optimization of Amanitin-Based RNA Polymerase II Inhibitor Payloads for TROP2 Targeting ADCs 11:15 am

Understanding the evolution from first-generation (HTP101) to second-generation amanitin payloads demonstrating improved targeting capabilities through both cleavable and non-cleavable linker strategies Outlining structural optimization of amanitin payload to enhance overall performance Discussing the efficacy of TROP2-expressing tumors in both pancreatic and triplenegative breast cancer modelsRead more

day: Conference Day One