Discovering a Novel Mechanism of Action for ADC Payloads by Using Amatoxins as RNA Polymerase II Inhibitors

Time: 2:30 pm
day: Conference Day One


  • Understanding why we chose to inhibit RNA-Polymerase II and the unique mode of action of amatoxins
  • Identifying useful biomarkers to evaluate amatoxin susceptibility in tumors
  • Outlining the benefits of adapting a novel payload with unique mode of action vs. a well understood, clinically validated drug