Optimizing Homogenous Top1i ADCs: Discovery of hydrophilic β-Glucuronidase Cleavable Topo1 Inhibitor Linker Payloads for Enhanced Efficacy & Safety

Time: 9:15 am
day: Conference Day One


  • Exploration of novel linker-payload attributes that improve safety and therapeutic index
  • Highlighting the significance of tumor-selective linker chemistry in enhancing the efficacy and therapeutic index of aTF ADCs
  • Exploring the synergetic efficacy of Topo1 inhibitor ADCs in combination with diverse DNA repair inhibitors to overcome the resistance