Exploring Schlafen 11 as a Cellular Determinant of Response to TOP1 Inhibitor Payloads, Including Non-Campothecin and Synergistic Drug Combinations

Time: 9:45 am
day: Conference Day One


  • Establishing the molecular mechanism of action of TOP1 poisons and potential synergistic drug combinations with TOP1 poisons
  • Emphasizing the importance of using Schlafen 11 (SLFN11) as determinant of response to TOP1 inhibitor payloads
  • Showcasing non-camptothecin TOP1 inhibitors as improved options for TOP1 payloads