Overcoming Challenges in Using STING Payloads: Identification of a Novel Linker Enabling Bioconjugation of a Cyclic Dinucleotide for the STING Payload Antibody Drug Conjugate TAK-500
Time: 2:00 pm
day: Conference Day One
Details:
- Identifying a cleavable linker and self-immolative spacer with acceptable plasma stability for a cyclic dinucleotide STING agonist with no available functional group
- Understanding how DAR affects PK profile, and considerations when using a STING agonist payload
- Demonstrating in vivo immune cell activation and antitumor activities using STING ADC
