Overcoming Challenges in Using STING Payloads: Identification of a Novel Linker Enabling Bioconjugation of a Cyclic Dinucleotide for the STING Payload Antibody Drug Conjugate TAK-500

Time: 2:00 pm
day: Conference Day One


  • Identifying a cleavable linker and self-immolative spacer with acceptable plasma stability for a cyclic dinucleotide STING agonist with no available functional group
  • Understanding how DAR affects PK profile, and considerations when using a STING agonist payload
  • Demonstrating in vivo immune cell activation and antitumor activities using STING ADC